Liko martin biography templates
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Abstract
Adrenocortical carcinoma (ACC) is an aggressive tumor showing frequent metastatic spread and poor survival. Although recent genome-wide studies of ACC have contributed to our understanding of the disease, major challenges remain for both diagnostic and prognostic assessments. The aim of this study was to identify specific microRNAs (miRNAs) associated with malignancy and survival of ACC patients. miRNA expression profiles were determined in a series of ACC, adenoma, and normal cortices using microarray. A subset of miRNAs showed distinct expression patterns in the ACC compared with adrenal cortices and adenomas. Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed, while miR-195, miR-497, and miR-1974 were underexpressed in ACC. Inhibition of miR-483-3p or miR-483-5p and overexpression of miR-195 or miR-497 reduced fängelse proliferation in human NCI-H295R ACC cells. In addition, downregulation of miR-483-3p, but not miR-483-5p
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Disclaimer: Of course the importance of Mauna Kea is “really” about so much more than this small slice of the issue. However, this tedious TMT PR trope of asking “can science and culture coexist on the mountain” is making me slightly insane. Here’s another angle–the way we should “really” be asking this question. But first, a public service announcement.
Today, October 5th, is the worldwide celebration of Aloha ʻĀina Unity Marches, with events taking place on most or all of the Hawaiian Islands and in other places besides. (Aloha ʻĀina means “love the land.”)
The controversy over the construction of a massive, ecologically destructive, 18-story building on stolen lands in a fragile “conservation district” zone–a district located on Mauna Kea, one of the most sacred mountains in the Pacific–is often presented as “Science” (white, western, mostly based on mater • Centeno PP, Chester C, Ford CA, Ridgway RA, Cammareri P, Jamieson T, Marais R, Campbell AD, Sansom OJ. Epidermal tumour-resistant progenitors require SOX2-driven developmental reprogramming to drive tumorigenesis. bioRxiv. 2025:2025.2001.2023.634502. Goodwin RJA, Marshall JF, Poulogiannis G, Yuneva M, Brindle KM, Takáts Z, Sansom OJ, Bunch J, Barry ST. Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta. Cancer Discov. 2025(1):34-38. Mzoughi S, Schwarz M, Wang X, Demircioglu D, Ulukaya G, Mohammed K, Zorgati H, Torre D, Tomalin LE, Di Tullio F, Company C, Dramaretska Y, Leushacke M, Giotti B, Lannagan TR, Lozano-Ojalvo D, Karras P, Vermeulen PB, Hasson D, Sebra R, Tsankov AM, Sansom OJ, Marine JC, Barker N, Gargiulo G, Guccione E. Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer. Nat Genet. 202
Prof Owen Sansom FRSE, FMEDSci - Colorectal Cancer and Wnt Signalling
Recent Publications
2025